The best of both worlds:Adaptation during natural tasks produces long-lasting plasticity in perceptu

来源 :第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis | 被引量 : 0次 | 上传用户:taomeizi2006
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  In human vision,one eye is usually stronger than the other,a phenomenon called ocular dominance.Extremely imbalanced ocular dominance can be found among certain patient groups,e.g.in amblyopia.The present work introduces a novel method to rebalance sensory ocular dominance.We developed an “altered reality” system,with which subjects could interact with the natural world that had been changed through real-time image process.A single three hour of adaptation session produced effects lasting for at least 1 week.Five such session over successive days produced larger effects and triggered surprising additional strengthening over the subsequent 2 months,when subjects only experienced natural vision.Testing in amblyopic subjects indicated that the method can produce substantial increases in visual acuity in the suppressed eye.One advantage of this,and other adaptation-based methods,is that it allows subjects to perform normal everyday activities,without supervision.Past adaptation-based methods have produced relatively shortlasting effects,however.Perceptual training on specific tasks has been shown to produce much longer-lasting effects,but this requires dedicated practice sessions and possible supervision; it may also lead to over-training on the tasks that could limit the generalization of improvement.Our method combines the advantages of both approaches,effectively training subjects to use both eyes in the wide variety of everyday tasks.The transfer of this training to their everyday vision likely produced the continuing growth in effects during the months after the training.The combination of both past approaches into a long-term wearable device make our method a promising approach for treatment of disorders such as amblyopia.
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