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Mimicking microenvironment of native tissue is a critical issue for effective tissue regeneration.Particularly,in the cases of load-bearing tissues such as articular cartilage or bone,mechanical cues and sustained biological cues are important factors.Various carriers including hydrogels and nanoparticles have been investigated to achieve the sustained release of protein drugs.However,it is difficult to apply these carriers alone as a scaffold for cartilage regeneration because of their weak mechanical properties.