Polymer conjugation to increase stability and reduce toxicity of peptides:Oxytocin and Colistin

• 作 者: David M.Haddleton Jennifer Collins Chongyu Zhu Paul Williams Kristian Kempe
• 机 构: Department of Chemistry,University of Warwick,Coventry,CV47AL,UK
• 出 处: Fourth Symposium on Innovative Polymers for Controlled Deliv
• 发表日期: 2016年11期
• 关键词: bioconjugation oxytocin colistin living radical polymerisation

　　Polymer conjugation,and in particular pegylation,has been used with spectacular success in therapeutics combining polymer science with pharmacy giving rise to the field of nanomedicine.Advances in living radical polymerisation have provided either solutions or inspiration in this area.We have been working with collaborators in MIPS on combining polymers with both oxytocin and colistin to 1) improve stability and 2) reduce toxicity.