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刺激诱发出的节律性、周期性或者发作期放电(Stimulus-induced rhythmic,periodic,or ictal discharges,SIRPIDs)是Hirsch等在2004年首次命名的一种脑电现象,在意识障碍或者昏迷患者的长程脑电监测中所得。SIRPIDs机制可能与皮层下-皮层功能异常相关,尤其与丘脑皮层回路功能异常相关。但目前研究对于这一现象的病理生理学机制不甚明确。部分研究认为出现这一脑电现象提示患者预后较差,但从现有研究来看,该异常脑电活动能否引起神经损伤,或者这些异常是否仅仅为脑损伤严重的表现,以及是否需要药物干预治疗,临床中尚无法确定。文章目的是综述现有的文献了解SIRPIDs的概念、病理生理学机制、临床相关性,以及其对于神经重症患者脑功能的提示。
Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs) are the first EEG phenomena named by Hirsch et al. In 2004. They have long-term effects on patients with unconsciousness or coma EEG monitoring obtained. The mechanism of SIRPIDs may be related to abnormalities of subcortical-cortical functions, especially dysfunction of thalamocortical circuits. However, the current research on the pathophysiology of this phenomenon is not clear. Some studies suggest that the occurrence of this EEG phenomenon suggests that the prognosis of patients is poor, but from the existing studies, whether the abnormal EEG can cause nerve damage, or whether these abnormalities are only serious manifestations of brain damage, and the need for drugs Intervention treatment, clinical still can not be sure. The purpose of this article is to review the literature available to understand the concept of SIRPIDs, their pathophysiological mechanisms, clinical relevance, and their implications for brain function in patients with neuroticism.