Expression of hepcidin at the choroid plexus in normal aging rats is associated with IL-6/Stat3 sign

• 作 者: LIUChong-Bin[1]WANGRui[2]DONGMiao-Wu[3]GAOXi-Ren[2]YUFeng[2]
• 机 构: Department of Physiology,School of Medicine,Huzhou Normal College,Huzhou 313000,China
• 出 处: 第二届中国国际生物微量元素大会
• 发表日期: 2014年期

　　Accumulating evidence has revealed that brain iron concentrations increase with aging, and the choroid plexus may be at the basis of iron-mediated toxicity and the increase in inflammation and oxidative stress that occurs with aging.It includes not only hepcidin, the key hormone in iron metabolism, but also iron-related proteins and signaling-transduction molecules, such as IL-6 and signal transducer and activator of transcription 3, which becomes phosphorylated.