【摘 要】
：
Objective: Glucocorticoid-induced TNFR-related (GITR) is a gene coding for a member of the TNF receptor superfamily.After activated by its ligand GITRL, GITR could influence the activity of effector a
【机 构】
：
Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, 210029
论文部分内容阅读
Objective: Glucocorticoid-induced TNFR-related (GITR) is a gene coding for a member of the TNF receptor superfamily.After activated by its ligand GITRL, GITR could influence the activity of effector and regulatory T cells, participating in the development of several autoimmune and inflammatory diseases included rheumatoid arthritis and autoimmune thyroid disease.
其他文献
Objective: This study investigates the relationship between serum adiponectin level and thoracic aortic calcification (TAC) in 333 Chinese elderly over the age of 65.Methods: This is a cross-sectional
Objective: Arterial calcification is a common event in cardiovascular pathogenesis.Osteoblastic differentiation of vascular smooth muscle cells (VSMCs) is the most important cytopathologic foundation
Multiple symmetric lipomatosis (MSL)is a rare disease characterized by symmetric and abnormal distribution of subcutaneous adipose tissue (SAT);however, the etiology is largely unknown.We report here
MicroRNAs play an important regulatory role during adipogenesis, and have been studied extensively in this regard.Specifically, the switch between differentiation of mesenchymal stem cells (MSCs) towa
Abnormal levels of mammalian target of rapamycin (mTOR) signaling have been recently implicated in the pathophysiology of neurodegenerative diseases, such as Alzheimers disease (AD).The implication of
The aim of our study is to evaluate the efficacy and safety of endothelial progenitor cells (EPCs) transplantation and glucagon-like peptide 1 (GLP-1) receptor agonist intervention on hindlimb ischemi
Objective: To investigate the relationship between serum Secreted protein acidic and rich in cysteine (SPARC), Angiopoietin-like protein 4 (ANGPTL4) and obesity in type 2 diabetes mellitus.Methods: Ac
Aim: To explore the effects of pioglitazone on the levels of TNF-a, IL-6 and BDNF in hippocampus of obese rats induced by ovariectomized and high-fat diet.Methods: Thirty female Wistar rats, age 3 mon
目的：探讨综合性护理在类克(类克英夫利昔单抗)治疗强直性脊柱炎的应用效果。方法：将在我科使用类克治疗强直性脊柱炎82例患者随机分两组，为观察组和对照组各41例，观察组依据综合性护理路径和流程进行治疗、护理，对照组采用传统方法进行治疗、护理。对比2组患者患者满意度及用药并发症。结果：实验组对护理工作的满意度提高，用药并发症减少。结论：类克治疗强直性脊柱炎应用综合性护理是一种行之有效的工作方式。
强直性脊柱炎(AS)是常见的炎性关节病之一,以骶髂关节炎、肌腱端炎和脊柱炎为特点,晚期可发生脊柱强直、畸形以致功能严重受损,具有潜在的致残性。现有研究表明,AS患者体内存在明显的成骨过度现象及经典Wnt信号通路抑制因子DKK-1异常表达,提示Wnt信号转导通路可能在AS的新骨形成过程中发挥重要的作用。本文对目前Wnt信号转导通路的研究进展及其在强直性脊柱炎中的相关研究作一综述。