【摘 要】
：
1,5-Benzodiazepine and its derivatives have attracted considerable attention as an important class of heterocyclic compounds in the field of drugs and pharmaceuticals [1].These compounds are widely us
【机 构】
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The College of Chemistry and Material Science,Hebei Normal University,Shijiazhuang 050024
【出 处】
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中国化学会全国第十二届有机合成化学学术研讨会
论文部分内容阅读
1,5-Benzodiazepine and its derivatives have attracted considerable attention as an important class of heterocyclic compounds in the field of drugs and pharmaceuticals [1].These compounds are widely used as anticonvulsant,anti-anxiety,anti-depressive,antibacterial agents.In recent years,1,5-benzodiazepine and its derivatives have been also reported to exhibit excellent antimicrobial activity [2].Additionally,previous studies on 1,5-benzodiazepines have indicated that the free ester group present at different positions in the nuclei of the molecules could enhance the pharmacological properties of the compounds,and this effect is attributed to their high hydrophobicity.
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吡啶并[1,2-a]咪唑类化合物在医药领域表现出了良好的生物和药物活性[1],而此类化合物的药物活性则取决去其不同位置所联有的官能团。在各种各样的吡啶并[1,2-a]咪唑类化合物当中,其亚硝基化的化合物由于在生物代谢过程中的重要作用受到了广泛的关注[2],并且此类化合物是许多化学反应,如aldol 反应、Diels-Alder 反应以及环加成反应等的中间体。
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