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Objective: Microalbuminuria is widely accepted as the first clinical sign of diabetic nephropathy.However, normoalbuminuric type 2 diabetic patients who have renal insufficiency exist.Information on normoalbuminuric patients with type 2 diabetes is scarce.We explored to approach the impact factors correlated with normoalbuminuric renal insufficiency in type 2 diabetes.Methods: We collected the data of type 2 diabetic patients in our hospital between 1994 and 2008, whose measurements of urinary albumin excretion rate were within the normoalbuminuric range.Patients were divided to two groups on the basis of their glomerular filtration rate (GFR) estimation, the group of renal sufficiency with GFR ≥60ml/(min.1.73m2) and the group of renal insufficiency with GFR <60ml/(min.1.73m2).GFR was measured by the plasma disappearance of isotopic 99mTc-diethylene-triamine-penta-acetic acid (DTPA) with single-photon emission computed tomography.The clinical and biochemical iterms were compared and analyzed between the two groups, which included Sex, Age, Body mass index, Duration of diabetes, History of hypertension, Systole blood pressure, Diastolic blood pressure, Glycated hemoglobin, Total cholesterol, Total triglyceride, High-density lipoprotein, Low-density lipoprotein and Blood uric acid.Results are given as mean±SD.Statistical significance of the differences between the groups was determined by chi-squared tests for categorical variables and t-test for continuous variables.Multiple logistic regression was used to describe the associations of variables with the presence of renal insufficiency for potential confounders.Results: A total of 122 cases were examined, including 57 males and 65 females.They were 24 to 85 years old with the average age of 58.94.There were 90(73.8%) in the group of renal sufficiency and 32 (26.3 %) in the group of renal insufficiency.Their data were not different from those of the 122 patients in terms of Body mass index, Duration of diabetes, Diastolic blood pressure, Glycated hemoglobin, Total cholesterol, Total triglyceride, High-density lipoprotein and Low-density lipoprotein, and significant differences in Sex, Age, History of hypertension, Systolic blood pressure and Blood uric acid.The results of multiple logistic regression showed that Sex,Age, Body mass index, Duration of diabetes and History of hypertension were independently associated impact factors of normoalbuminuric renal insufficiency in type 2 diabetes patients.Normoalbuminuric patients with renal insufficiency were significantly older, fatter and more commonly male in comparison to those with normal renal function.They were more likely consolidated with hypertension and high blood uric acid.Conclusions: Overall sex, age, BMI, the duration of diabetes and history of hypertension were independently associated impact factors of normoalbuminuric renal insufficiency in type 2 diabetes patients.Available prevention and treatment aimed directly at the above impact factors could delay the progression of renal insufficiency.