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目的建立四氯化碳致大鼠肝硬化腹水动物模型,并利用该模型进行犬血白蛋白(plasma derived canine serum albu-min,pCSA)在体内的治疗实验,评价pCSA治疗肝硬化腹水的效果。方法采用每周2次腹腔注射剂量为2ml/kg wt40%四氯化碳-橄榄油混合溶液的方法,诱导正常成年Wistar大鼠产生
Objective To establish an animal model of cirrhotic ascites caused by carbon tetrachloride (CCl4) in rats and to evaluate the therapeutic effect of pCSA in the treatment of ascites due to cirrhosis of the liver by using the model to treat in vivo the plasma derived canine serum albu-min (pCSA). Methods Normal adult Wistar rats were induced by intraperitoneal injection of 2ml / kg wt40% carbon tetrachloride - olive oil twice a week