【摘 要】
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The small RNA and Argonaute pathways are known to be involved in fundamental cellular processes and disease by suppressing the expression of sequences that
【出 处】
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2015非编码RNA和表观遗传学研究经验交流会
论文部分内容阅读
The small RNA and Argonaute pathways are known to be involved in fundamental cellular processes and disease by suppressing the expression of sequences that are harmful to the genome or the expression of endogenous genes.Such suppression occurs at almost all levels of gene expression regulation ranging from DNA elimination, transcriptional, epigenetic, posttranscriptional and translational, and collectively known as RNA interference (RNAi).Recently, small RNAs have also been found to partner with Argonautes to positively regulate gene expression at the transcriptional/epigenetic levels, a phenomenon which has been termed RNA activation (RNAa).I will talk about our new understanding of the mechanism of RNAa and a potential role of microRNA-mediated RNAa in cancer.
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