论文部分内容阅读
CD4+ Th17 cells can activate CD8+ cytotoxic T lymphocytes (CTL) and induce antitumor immunity leading to eradication of established tumors.However, the mechanism of CTL activation by Th 17 cells and the distinct role of Th 17 and Th 17 activated CTLs in antitumor immunity are still elusive.In this study, we generated ovalbumin (OVA) specific Th17 cells by cultivating OVA-pulsed dendritic cells with CD4+ T cells derived from transgenic OTII mice in presence of IL-6, IL-23, TGF-β and anti-IFN-γ antibody.