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This study investigated fracture toughness values of five dental indirect resin composites under the effect of thermal cycling by single-edge notched beam method.Five commercial dental restorative resins were included in the research.AP-X(micro-hybrid resin composite),FiltekP60(micro-hybrid resin composite with zirconia particles),Z350(micro-filled resin composite with zirconia particles),VITA ZETA(nano-filled composite),VITA LC(nano-filled composite).After thermal cycling,significant changes of fracture toughness were found for the tested composites except AP-X.Micro-differences between SEM images with and without thermal cycling were observed.It is concluded that irregular-shaped fillers and higher filler content contribute to higher mechanical properties,and result in superior fracture toughness under the effect of thermal cycling.