论文部分内容阅读
According to the inflammation immune feature of the tumor microenvironment, a novel self-targeting anticancer drug delivery system is developed based on immune cell carrier for drug-loaded liposomes mediated by the amplified tumor inflammation reaction.Thermotherapy of PEGylated gold nanorods (PEG-AuNRs) can activate and amplify controllably tumor chemokines, which could be tumor targeting signals to recruit intravenously administrated drug-loaded immune cell.In this study, an unprecedented cell carrier, Paclitaxel(PTX)-liposome loaded immune cell was designed to target tumor cell in response to inflammatory signal amlpified by PEG-AuNRs photothermal therapy.In vivo imagings showed PTX-liposome loaded immune cell accumulates to tumor over 48 h longer than PTX-liposome and Taxol, and nearly the same as Lipopolysaccharides(LPS)-mediated inflammation after photothermal therapy.Most importantly, in vivo experiments also showed that the cell carrier could significantly decrease organ toxicity and enhance the antitumor efficacy compared with PTX-liposome and Taxol, indicating a promising biocompatible carrier for targeted cancer therapy.