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The v ast majority o f p harmaceutical i ntermediates a nd en d p roducts ar e produced b y s ynthesis,which requires a combination of chemicals,a solvent into which they are mixed,and a reaction process to produce the desired pharmaceuticals.After t he d esired P harmaceutical I ngredients(APIs)i s s ynthesized,series o f p rocesses o ften involving e xtraction,c rystallization,f iltration,and dr ying a re needed.S olvent d rying is o ften t he most e nergy intensive unit operation and a major manufacturing bottleneck due to its relatively long processing times.Therefore,accurately determination of the true drying end point can easily save at least 25%of the time and energy of the pharmaceutical manufactures.N ear Infrared(NIR)spectroscopy and Mid Infrared(MIR)spectroscopy have been proposed a s s uitable methods f or monitoring dr yer pe rformance a nd de tecting t he e nd poi nt.H owever,t hese approaches r equire the d evelopment o f co mplex ch emometric m odels t o map t he measured s pectra t o s olvent concentrations.I n addition,interfacing t hese techniques with various vacuum drying s ystem i s very difficult and sometime it is impossible.In this p resentation,u sing MS monitoring the headspace composition above the drying material to tell the true drying end points will be demonstrated,because it has been long proved that the headspace materials composition is directly correlated to the concentration of solvents in the material.T he Quadrupole Mass Spectrometer is used to monitor concentration profiles of solvents over time to determine the exact moment the drying is complete.Many proven pharmaceutical cases will be discussed as well.