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Notch receptors communicate short-range signals through a self-destructive process.Although Notch 1 and Notch2 are closely related paralogs and function through the same canonical pathway, they do contribute to different outcomes in some cell and disease contexts.To understand the basis for these differences we examined in signal "composition" and signal "strength" in detail using mouse genetics and new Notch receptors in which N1ICD and N2ICD were swapped.Our data point to the conclusion that strength (defined here as the ultimate number of intracellular domain molecules reaching the nucleus, integrating ligand-mediated release and nuclear translocation) and duration (half life of NICD/RBPjk/MAML/DNA complexes, integrating cooperativity and stability dependent on shared sequence elements) are the factors that underlies much of the differences between Notch1 and Notch2 in all the contexts we examined.I will present this data, and suggest a reinterpretation of clinical findings segregating differential outcome with Notch 1 or Notch2 are likely to reflect dependent the overall strength of Notch signals.I will also discuss some ideas for measuring strength.