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Bisphenol A,a synthetic additive used to harden polycarbonate plastics and epoxy resin,is ubiquitous in our dailylife.BPA is an industrial plasticizer that leaches from food containers during normal usage leading to humanexposure.Early and chronic exposure to endocrine disrupting environmental contaminants such as BPA elevates thepotential for long term health consequences.Many studies indicated detrimental effects of BPA on mammalianreproductive abilities.We used the mise as a model,trying to find the evidence of BPA damaged human reproductivehealth,probing if BPA effects the process of DNA methylation at imprinted genes in sperm cells and against thesemen quality and next generation of mouse leading to the infertility of male.This study is aimed to explore the roleof BPA to the growth of sperm cells at each period in the spermatogenesis,reveal the evidence of BPA against thesemen quality and next generation of mouse.Our results demonstrated that BPA promotes estrogen receptor inmRNA and protein levels expression during the differentiation of male mouse germ cells,induces the increasing ofestrogen levels in blood,and speeds up the process of meiosis in male mouse germ cells,resulting in the leading topremature decay.However,BPA has no effect on the methylation of imprinted gene Igf2,Igf2r,Peg3,and H19.We also confirm BPA having the influence of the male germ cells,affecting the normal changes from spermatogeniccells to the sperm cells,and accelerating the decline of spermatogenesis in male mouse.In addition,BPA lead to theabnormal fertility in mouse of 49 days after birth by the way of observing the growth and developmentalabnormalities of offspring by BPA treating male mouse with untreating female mouse.In conclusion,BPA speeds upthe process of meiosis germ cells in mouse and makes mature and quality of the germ cells unusual in mouse bymeans of affecting estrogen receptor signaling pathway in mouse germ cells.