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A vaccine is the best solution to stop the AIDS pandemic,but how to develop it has been an unprecedented challenge to the global scientific community.China CDCs HIV vaccine research strategy includes:selecting the most prevalent circulating HIV-1 strains,optimizing the vaccine antigen design through learning from the worlds first successful lentivirus (EIAV) vaccine,and using the replication competent viral vector Tiantan vaccinia (rTV),the Chinese small pox vaccine.