论文部分内容阅读
The purpose of this study was to explore factors associated with recurrence of adenoid cystic carcinomas (ACCs).We examined recurrence values of clinicopathologic variables, GLUT-1, p-Akt, and PI3K expression in 42 patients with ACC.Of the 42 patients, seventeen developed recurrence after initial surgery.The positive rate of GLUT-1,PI3K, and p-Akt protein in ACC was 38.1%, 38.1%, and 50.0%, respectively.T Expression of GLUT-1 or p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors.Our study has demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy, and expression of GLUT-1, PI3K, and p-Akt were factors predictive of recurrence by univariate analyses.In multivariable analysis, perineural invasion, resection margin positive and p-Akt were significant predictors of recurrence.Initial surgery is very important for recurrence of ACC.Overexpression ofGLUT-1, PI3K, and p-Akt may play a role in development recurrence of ACC.