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Objective Exosomes are a kind of membranous,nanosized endocytic vesicles and they contain an abundant cargo of biological active substances,including different protein and RNA species that can modulate the behavior of cells and may be acted as potential biomarkers for different diseases.Circular RNAs(circRNAs)from back-spliced exons have been recently identified as naturally occurring family of non-coding RNAs that may regulate gene expression and they can be sorted into exosomes.