Chemical Mutations on Specific Nucleobases as a Feasible Approach for More Efficient DNAzymes

• 作 者: QiWang[1]YangLiu[1]WeiRong[2]JianpingYu[2]DiZhang[3]MaoshengCheng[3]KeliangLiu[1]JunlinHe[4]
• 机 构: Beijing Institute of Pharmacology and Toxicology,27 Taiping Road,Beijing 100850
• 出 处: 第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
• 发表日期: 2012年期

　　Residue replacement of functional nucleic acids is the first choice for their structure-activity relationship and better performance,in the absence of active conformation.Two small DNAzymes,10-23 as genetic therapeutics against many disease-related genes and 8-17 DNAzyme as biosensors,have been studied extensively.Canonical residue replacement and deletion confirmed the conservation of the catalytic cores,and no better analogs could be obtained by this way.