Angiotensin-(1-7)decreases the expression of collagen Ⅰ via TGF-β1/Smad2/3 and subsequently inhibits

• 作 者: Jian PingZhou YunFeng Qing YunLi Huan YingWan
• 机 构: Department of Respiratory Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,
• 出 处: 2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议
• 发表日期: 2016年4期
• 关键词: Airway remodeling HLF-MF transition Angiotensin-(1-7) TGF-β1 Collagen-Ⅰ Signalin

　　目的 Previous studies have shown that renin-angiotensin system (RAS) might participate in airway remodeling in asthma.As a main component in RAS,Angiotensin-(1-7) [Ang-(1-7)] has been reported in few studies regarding its protective effect on asthma.However,the functional roles and relevant signaling pathways of Ang-(1-7) have not been well illustrated.In the present study,we intended to analyze the effect of Ang-(1-7) on Angiotensin Ⅱ (AngⅡ)-induced human lung fibroblast (HLF)-myofibroblast (MF) transition by detecting collagen type Ⅰ (Col-Ⅰ),transforming growth factor-beta 1(TGF-β1) and α-smooth muscle actins (α-SMA) expression.We further explored the possible signaling pathways involved in HLF-MF transition.