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@@ Purpose: To evaluate whether segmented breath-hold technique can be used in diffusion-weighted MR imaging (DW-MRI), and generate high-b-value images of gastric cancer through sensitivity encoding technique (ASSET) combined with multi-acquisition method.Materials and Methods: Three ASSET DW-EPI sequences with different number of acquisitions (NEX=1, 2, 4) were performed in 16 patients on a 1.5T MR scanner (GE Signa EXCITE). All patients were proved pathologically advanced gastric cancer by endoscopic guided biopsy. When acquisition time exceeded 15 seconds, a function "pause" key was used to make the scan pause after the current TR complete. Then the patients took several breaths, and completed the rest scanning in another breath-hold. Depending on patients endurance time, the DW-MRI sequences were segmented into 1-3 breath-holds. Scan parameters include: TR/TE, 2575ms/65ms; matrix, 128 ?28; section thickness/intersection gap, 5mm/lmm; slice number, 12; FOV, 36cm?6cm. The b values were 0, 1000s/mm2, and the MPG pulses were placed in 3 directions. Two radiologists evaluated images according to the grade of artifacts and cancer-to-background CNR (CNRCa-Bg). The artifacts were classified into 3 grades: grade 1, no obvious artifact; grade 2, obvious artifacts without influencing cancer identification and apparent diffusion coefficient (ADC) measurement; grade 3, obvious artifacts influencing cancer identification or/and ADC measurement. The ADCs of tumors and water in gastric lumen were measured.