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The neurons produce sequential spikes as digital codes, and their various patterns constitute the brain programs of managing cognition and behaviors.A source for physiologically integrated synaptic signals to initiate digital spikes remains unknown, which we studied at pyramidal neurons of cortical slices.In dual recordings from the soma vs.axon, the signals recorded in vivo induce somatic spikes with higher capacity, which is associated with lower somatic thresholds and shorter refractory periods mediated by voltage-gated sodium channels.The introduction of these parameters from the soma and axon into NEURON model simulates sequential spikes being somatic in origin.Physiological synaptic inputs primarily trigger the soma to encode neuronal digital signals.