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[目的]分析2007年海南省健康人群的流脑IgG抗体水平及流行病学分布特征,为制订更为科学的流脑防控方案提供理论依据。[方法]采集监测点健康人群血标本,进行脑A群、C群流脑IgG抗体定量检测,根据抗体检测结果结合年龄、性别等因素进行统计学分析。[结果]2007年共检测健康人群血标本614份,其中A群流脑抗体阳性率为68.73%(422/614),C群流脑抗体阳性率为11.56%(71/614),两者抗体阳性率比较差异有统计学意义。4个监测点间比较,海口市A群及C群抗体阳性率均较高。“15岁～”年龄组A群和C群流脑IgG抗体阳性率均最高。流脑IgG抗体的Nemenyi分析,A群抗体浓度各组间没有差异,C群“15岁～”年龄组抗体浓度最高,“﹤1岁”和“7岁～”两个年龄组较低。[结论]目前我省健康人群流脑抗体阳性率A群和C群均不高,尤其是C群流脑IgG抗体阳性率仅为11.56%,不能形成有效的免疫屏障。加强扩大免疫规划后15岁以下适龄儿童的流脑A群或A+C群疫苗接种,尽快提高我省人群的免疫力,具有重要的现实意义。
[Objective] To analyze the level and epidemiological characteristics of cerebrospinal fluid IgG in healthy population in Hainan Province in 2007, and provide a theoretical basis for making a more scientific plan of prevention and control of meningitis. [Methods] Blood samples were collected from healthy population at monitoring sites for quantitative detection of cerebrum antibodies of brain A and C populations. Statistical analysis was made based on antibody test results combined with age and gender. [Results] A total of 614 blood samples were detected in healthy population in 2007, of which the positive rate of meningococcal antibody in group A was 68.73% (422/614), the positive rate of mecca antibody in group C was 11.56% (71/614) The positive rate of the difference was statistically significant. Among the four monitoring sites, the positive rates of antibody of group A and group C were higher in Haikou City. The positive rates of IgG antibodies in Group A and Group C meningitis in “15-year-old” age group were the highest. Nemenyi analysis of IgG in the meningitis group showed no difference in antibody concentration of group A between the two groups, with the highest concentration of antibody in group C Lower age group. [Conclusion] At present, the positive rates of meningococcal antibody in healthy people in our province are not high, and the positive rate of IgG antibodies in group C meningitis is only 11.56%, which can not form an effective immune barrier. It is of great practical significance to strengthen the vaccination of meningitis A group or A + C group of children under the age of 15 after enlarging the immunization program so as to improve the immunity of our province’s population as soon as possible.