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Multifunctional nanoparticles are attracting increasing attention as novel agents for efficient tumor therapy.In this study, a core-shell nanoparticle(NP) system is synthesized by growing gelatin-doxorubicin (Gel-DOX)-stabilized Prussian blue (PB)nanoshells on Fe3O4 nanocores (Fe3O4@PB@Gel-DOX NP), for combined photothermal therapy and enzyme-responsive chemotherapy under magnetic field menhancement.