Structure-Activity Relationships Study of PARP-1 Inhibitors

• 作 者: Hongyan Yin A Yan
• 机 构: Department of Pharmaceutical Engineering,Beijing University of Chemical Technology,No.15,North Third
• 出 处: 2019中国化学会第十五届全国计算(机)化学学术会议
• 发表日期: 2019年3期
• 关键词: PARP-1 inhibitors random forest (RF) support vector machine (SVM) classification

　　Poly-ADP-ribose polymerase 1(PARP-1)is the highest content isoform of PARPs and the inhibition of PARP-1 is considered a promising anticancer strategy.