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Background Despite the popularity of coronary stenting in coronary artery disease (CAD), restenosis remains a challenging clinical problem.We aim to test whether serum level of matrix metalloproteinase (MMP)-9 is associated with the development of in-stent restenosis (ISR) in patients treated with drug-eluting stents (DES).Methods 120 patients who were treated with DES were enrolled into our study.Blood samples for measurement of MMP-9 antigen and activity were taken directly before and 48h after percutaneous coronary intervention (PCI).Restenosis was evaluated at 9-12 months by coronary angiography.