Traditional Chinese medicine improves neurological function after focal cerebral ischemia in rats

• 作 者: YANGCui-cui;ZHANGLan;ZHENGSha-sha;LUJie;ZHANGLi;LILin;
• 机 构: Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurod
• 出 处: 第十五届中国神经精神药理学学术会议
• 发表日期: 2012年期

　　OBJECTIVE To investigate the effects of CIG, an ingredient extracted from a traditional Chinese herb Cornus offici nalis, on neurological function and infarct size after ischemic stroke.METHODS SD rats underwent 90 rain of middle cere bral artery occlusion (MCAO).CIG was intragastrically admin istered to rats in dose of 60 mg·kg-1 ·d-1 , starting 6 h after the operation.The behavioral test was performed by using the modi fied neurological severity score (mNSS) at 2 ,7, 14, 21,28 d.Magnetic resonance imaging(MRI) was conducted at 2, 7, 14,and 28 d and then sacrificed and the infarct volume was meas ured using 2,3,5-Triphenyltetrazolium chloride (TTC) staining.RESULTS The treatment with CIG significantly improved neu rological function at 7, 14, and 28 d.MRIimaging demonstrated that total lesion volumes were reduced in the CIG group com pared with the model rats at 7, 14, 28 d.TTC staining showed that infarct volumes of the CIG group were significantly reduced at 28 d.CONCLUSION CIG treatment after 6 h ischemia im proved neurological function and reduced infarct size after ische mia in rats.