【摘 要】
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Background Diffuse panbronchiolitis #DPB#, a chronic inflammatory disease of the airway, is treated with macrolide antibiotics# The ability of azithromycin to improve DPB prognosis, as detected by CT
【机 构】
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Department of Pulmonary Medicine, affiliated Yixing people hospital, Jiangsu University, 214200, Chi
【出 处】
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中华医学会呼吸病学年会——2013第十四次全国呼吸病学学术会议
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Background Diffuse panbronchiolitis #DPB#, a chronic inflammatory disease of the airway, is treated with macrolide antibiotics# The ability of azithromycin to improve DPB prognosis, as detected by CT scans and lung function tests, has not been studied in a large cohort of patients# Our study aims to investigate the effects of azithromycin on patients with DPB using pulmonary function tests and radiologic images# Methods Twenty nine patients with DPB were studied;their medical records were collected and analyzed retrospectively# Patients studied were hospitalized in the respiratory department of the Yixing Hospital, affiliated with Jiangsu University# Azithromycin was administered for 6-17 months# Changes in lung function and CT scans after treatment with azithromycin for six months were compared with pre-treatment values and images respectively# Results Azithromycin therapy for six months resulted in rapid improvements in lung function, demonstrated by FEV1#0％, FEV1#0/FVC, and FEF75％ values# In addition, improvements were seen in small nodular shadows, dilated peripheral bronchi, bronchial wall thickening, and tree-in-bud pattern, as detected by chest CT scans# Conclusions Azithromycin can halt DPB progression and improve disease prognosis, as demonstrated by improvements in lung function and CT scans.
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