A series of new 1-phenylsulfonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives were designed,synthesized and evaluated as potential inhibitors of tubulin
COX-2 has long been exploited in the treatment of inflammation and relief of pain; however,research increasingly suggests COX-2 inhibitors might possess pot
Fatty acid biosynthesis is essential for bacterial survival.FabH,β-ketoacyl-acyl carrier protein (ACP) synthase III,is a particularly attractive target,since i
Novel benzenesulfonamide-substituted 1,5-diarylpyrazoles containing phenylacetohydrazide derivatives have been designed,synthesized and evaluated for their
The signal transducer and activator of transcription 3 is a constitutively activated oncogenic protein in various human tumors and represents a valid target