Accelerating mutant huntingtin degradation by nanoparticles through autophagy-lysosome or ubiquitin-

• 作 者: Pengfei Wei Li Zhang Yunjiao Zhang Peipei Jin Long-Ping Wen
• 机 构: Institute of Life Sciences,Key Laboratory of Biomedical Engineering of Guangdong Province,Key Labora
• 出 处: 第十一届全国化学生物学学术会议
• 发表日期: 2019年3期
• 关键词: Europium hydroxide nanorods Graphene oxide Autophagy-lysosomal pathway Huntingto

　　Accelerating the clearance of intracellular protein aggregates represents a viable approach for the treatment of neurodegenerative diseases.We have previously demonstrated enhanced degradation of mutant huntingtin protein aggregates through MEK/ERK1/2 signaling pathway regulated autophagy induced by europium hydroxide nanorods or graphene oxide nanoparticles.[1-3]