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BACKGROUND: Interleukin (IL)-3 5 is a novel heterodimeric cytokine in the IL-12 family.There are many evidences that demonstrated that IL-35 can efficiently suppress the T cell (such as Th1,Th2) activity and reduce the progression of autoimmune diseases and inflammatory diseases.However, current information about the levels of plasma IL-35 and its potential role in the field of coronary artery disease is still limited.Therefore, in our study, we measured the levels of plasma IL-35, YKL-40 and APN in different clinical presentations and the associations between them in order to determine its independency and predictive power.