阿霉素共价交联DNA的抗癌机制的单分子研究

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：zyy_2009

【摘要】

：

阿霉素是临床常用的广谱抗癌药，但其临床使用受到浓度依赖的心脏毒性的限制。阿霉素的主要作用机制被认为是抑制拓扑异构酶。然而拓扑异构酶的机制与心脏毒性密切相关。除拓扑异构酶的机制外，阿霉素还可被细胞内源的甲醛活化而共价结合至DNA 形成DNA交联，抑制DNA 和RNA 聚合酶产生细胞毒性。

【作者】

：

裴羽丰刘雅君谢春雨张兴华游慧娟

【机构】

：

华中科技大学同济医学院药学院,武汉,430030 武汉大学生命科学院,武汉,430072

【出处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

阿霉素抗肿瘤药物 DNA交联 DNA加合物单分子检测反应动力学

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阿霉素共价交联DNA的抗癌机制的单分子研究

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