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  5. Interim Evaluation of Efficacy or Futility in Group-sequential Clinical Trials With Multiple Co-prim

Interim Evaluation of Efficacy or Futility in Group-sequential Clinical Trials With Multiple Co-prim

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：lxm8154
【摘 要】
：
We discuss group-sequential designs in superiority clinical trials with multiple co-primary endpoints,i.e.,when trials are designed to evaluate if the test intervention is superior to the control on a
【作 者】
：
Toshimitsu Hamasaki Koko Asakura Scott R.Evans 
【机 构】
：
National Cerebral and Cardiovascular Center,565-8565,Japan
【出 处】
：
上海交通大学
【发表日期】
：
2016年4期
【关键词】
：
Error-spending method Futility Multiple endpoints Non-binding boundary Type Ⅰ an 
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　　We discuss group-sequential designs in superiority clinical trials with multiple co-primary endpoints,i.e.,when trials are designed to evaluate if the test intervention is superior to the control on all primary endpoints.We consider several decision-making frameworks for evaluating efficacy or futility,based on boundaries using group-sequential methodology.
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