论文部分内容阅读
The tumor suppressor CYLD contains a deubiquitinase domain and three cytoskeleton-associated protein glycine-rich domains.The tumor-suppressing function of CYLD has been attributed to its deubiquitinase domain, which removes lysine-63-linked polyubiquitin chains from target proteins, leading to the inhibition of cell survival and proliferation.In this study, we demonstrate that CYLD regulates the behavior of the mitotic spindle through its regulation of spindle microtubule dynamics and its deubiquitination of signaling proteins within the cell cortex.In addition, we find that CYLD regulates cytokinesis through its modulation of mitotic kinase activity on the central spindle and in the midbody.These findings suggest that CYLD plays a critical role in the regulation of mitotic progression, which might contribute to its tumor-suppressing function.