The mechanism of Ig alpha gene class switch recombination and Ig alpha heavy chain expression in can

• 作 者: Zhi Duan Ya Cao
• 机 构: 1CancerResearchInstitute,XiangyaSchoolofMedicine,CentralSouthUniversity110XiangyaRoad,Changsha,Hunan
• 出 处: 中国病理生理学会第十四届肿瘤专业委员会、第十五届免疫专业委员会联合学术会议
• 发表日期: 2014年11期
• 关键词: immunoglobulin class switch recombination activation-induced cytidinedeaminase (

　　It is traditionally believed that the production of immunoglobulin (Ig) molecules is restricted to B lymphocytes.All cells in human bodies include germline lg genes,when stimulated by foreign antigens and affected by various regulators,the Ig genes undergo V(D)J recombination,class switch recombination (CSR) and somatic hypermutation (SHM),only then can immunoglobulins be expressed in B lymphocytes.