Can the gut microbiota reduce cholesterol?Insights into pyrosequencing and metabolomics of Clostridi

• 作 者: Vijay Antharam Timothy J.Garrett Aaron T.Dossey Andrew Kozlov Eric Li Gary Wang David Wishart
• 机 构: Department of Medicine, Division of Infectious Diseases, University of Florida, Gainesville, FL 3261
• 出 处: 第四届国际人体微生态大会、第十三届中华预防医学会微生态学学术会议、第五届中国医师协会感染科医师大会暨传染病诊治高峰论坛、
• 发表日期: 2013年5期

　　Background Elevated cholesterol is widely associated with many pathologies; early research has shown highlevels of fecal cholesterol in ulcerative colitis and colon cancer subjects implicating aberrant cholesterol metabolism in these diseases.Surprisingly,members of the gut microbiota have been found to chemically reduce cholesterol at carbon 5 and 6 to generate coprostanol,a saturated sterol poorly absorbed and excreted into feces.