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Bombyx mori bidensovirus(BmBDV)of the family Bidnaviridae is a pathogen causing flacherie desease in silkworm and mainly infect the columnar cell of the silkworm larval midgut epithelium.Although several histopathological studies of BmBDV have been done,sequential pathological changes of silkworm larvae infected by BmBDV have not been completely studied.In this paper,detailed researches on sequential pathological features of BmBDV-infected larvae were performed.