Comparative analysis of D49 A2 and K49 A2 isolated from Macrovipera lebetina obtusa and Bothrops jar

来源 :8th IUPAP International Conference on Biological Physics(第八届 | 被引量 : 0次 | 上传用户：terreterre

【摘要】

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【作者】

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Narine Ghazaryan Lusine Ghulikyan Arsen Kishmiryan Naira Ayvazyan

【机构】

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Laboratory of Toxicology,Institute of Physiology NAS RA,Yerevan,Armenia

【出处】

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8th IUPAP International Conference on Biological Physics(第八届

【发表日期】

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2014年8期

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This study has shown the effect of various phospholipase A2 (PLA2) from snake venom of the family Vipridae on the giant unilamellar vesicles (GUVs) formed from phospholipids.We used 8-anilino-1-naphthalenesulfonicacid (ANS) as a fluorescence probe for GUVs visualization.Our results have shown that inhibition of PLA2with Ba2+ ions in the composition of the whole Macrovipera lebetina obtusa (MLO) venom significantly alters the character of influence of the venom on the vesicles.It has also been found that the PLA2 containing residues of aspartic acid and lysine at position 49 in the catalytic center have different effects on the vesicles.

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Comparative analysis of D49 A2 and K49 A2 isolated from Macrovipera lebetina obtusa and Bothrops jar

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