ENHANCED NK CELLS DEVELOPMENT IN HIS MICE BY hIL-21 OVEREXPRESSION IN VIVO

• 作 者: YanshiWang;YongyanChen;HaimingWei;RuiSun;ZhigangTian;
• 机 构: Institute of Immunology, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Li
• 出 处: The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会)
• 发表日期: 2015年期

　　Human immune system (HIS) protects human beings against microbe infection, but immunopathologic mechanisms are still unclear due to lack of a suitable animal model.Mice are the most useful experimental animals, but there are many differences between human and mice for the long period of evolution.Reconstitution of a functional HIS in mice will provide a powerful tool to study HIS physiology and pathophysiology.