头端延髓腹外侧区过表达血管紧张素转化酶2降低高血压大鼠中枢交感输出的机制研究

来源 :2012心血管疾病转化医学博士生学术论坛 | 被引量 : 0次 | 上传用户：wxwp_xu

【摘要】

：

血管紧张素转换酶2 (ACE2)是血管紧张素转化酶(ACE)的同系物，能够直接催化血管紧张素Ⅱ (AngⅡ)转换为血管紧张素1-7(Ang1-7)，通过激活Mas受体从而发挥降血压等心血管保护作用。在中枢神经系统内，头端延髓腹外侧区(RVLM)在血压和交感神经活动调控方面起到十分关键的作用，高血压交感输出增强与RVLM内兴奋性增强密切相关。

【出处】

：

2012心血管疾病转化医学博士生学术论坛

【发表日期】

：

2012年8期

【关键词】

：

高血压血管紧张素转化酶2 头端延髓腹外侧区交感神经活性

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头端延髓腹外侧区过表达血管紧张素转化酶2降低高血压大鼠中枢交感输出的机制研究

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