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Background:Hepatitis B virus(HBV)infection is still a worldwide disease which may cause liver cirrhosis or even hepatocellular carcinoma.Lamivudine is a potent nucleoside analogue used in treating chronic hepatitis B(CHB).However,resistance to the drug remains a problem.As early virological response can predict longterm efficacy of nucleotide analogue treatment,we analyzed all lamivudine recipients in this trial to determine the baseline characteristics and a model to predict early virological response reflecting the long-term effect of lamivudine.