【摘 要】
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1.Basal insulin requirement is approximately 30% of the total daily insulin dose in type 1 diabetic patients who use the insulin pump.To investigate the basal insulin requirement in total daily insuli
【机 构】
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Diabetes Therapeutics and Research Center, The University of Tokushima Japan
【出 处】
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MIT`s 1st Annual World Congress of Diabetes-2012(2012第一届糖尿病大
论文部分内容阅读
1.Basal insulin requirement is approximately 30% of the total daily insulin dose in type 1 diabetic patients who use the insulin pump.To investigate the basal insulin requirement in total daily insulin dose in Japanese type 1 diabetic patients, who use the insulin pump.The basal insulin requirement in 35 type 1 diabetic patients without detectable C-peptide using the insulin pump (Paradigm 712) was investigated during 2-3 weeks of hospitalization.The patients were served diabetic diets of 25-30 kcal/kg ideal body weight.Each meal omission was done to confirm stable blood glucose levels within 30 mg/dL variance until the next meal.Target blood glucose level was set at 100 mg/dL before each meal and 150 mg/dL at 2 h after each meal.Total daily insulin dose (TDD) was 31.6±8.5 units, and total basal insulin requirement was 8.7±2.9 units, which was 27.7±6.9% of the total daily dose.Basal insulin requirement is approximately 30%of the total daily dose in Japanese type 1 diabetic patients, who use the insulin pump.(Diabetes Care 2011;34, 1089-1090) 2.Carbohydrate-to-Insulin ratio is estimated from 300-400 divided by total daily insulin dose in type 1 diabetic patients who use the insulin pump, Carbohydrate-to-insulin ratio (CIR) of type 1 diabetic patients on insulin pump was investigated after adjustment of proper basal insulin rate.Forty-five inpatients with type 1 diabetes were served diabetic diets of 25-30 kcal/kg ideal body weight during several weeks of hospitalization.Each meal omission was done to confirm basal insulin rate.Target blood glucose level was set at 100 and 150 mg/dL before and 2 h after each meal, respectively.TDD, CIR, and these products were determined.TDD was 31.5±9.0 (means±SD) units.CIR x TDD of breakfast was significantly lower than those of lunch and supper (CIR x TDD: 288±73 v.s.408±92 and 387±83, respectively (p<0.01)).CIR has diurnal variance and is estimated from the formula;CIR equals 300 or 400 divided by TDD at breakfast, or lunch and supper, respectively, in type 1 diabetic patients on insulin pump.(In submission).
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