【摘 要】
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The objective of the study is to explore the possible association of the monocyte chemoattractant protein (MCP)-1-362G/C genetic polymorphism and plasma levels of MCP-1 in patients with spinal tubercu
【机 构】
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Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South Universi
【出 处】
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第三届全国脊柱结核诊疗新技术研讨会暨2017年湖南省医学会脊柱外科专业委员会年会
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The objective of the study is to explore the possible association of the monocyte chemoattractant protein (MCP)-1-362G/C genetic polymorphism and plasma levels of MCP-1 in patients with spinal tuberculosis (TB).The MCP-1-362G/C (rs2857656) polymorphism and blood levels of MCP-1 in patients with spinal TB and healthy subjects were evaluated and compared.Three hundred thirty-two patients and 336 healthy subjects were genotyped using polymerase chain reaction and Sanger DNA sequencing technology.MCP-1 plasma levels were measured by a solid-phase enzyme-linked immunosorbent assay.When comparisons were made between patients and controls,the frequency of the MCP-1-362C minor allele (55.4% versus 47.5%,P =0.004,odds ratio[OR]=1.376,95% confidence interval[CI]: 1.109-1.706) and the carriers of the MCP-1-362*C allele (80.7% versus 71.4%,P =0.005,OR =1.657,95% CI: 1.167-2.403) were over-represented in patients.The mean MCP-1 plasma level in spinal TB patients was significantly higher than in controls (154.44 ± 68.81 pg/mL versus 36.69 ± 21.71 pg/mL t =-5.85,P < 0,001).The patients with the CC genotype had the highest MCP-1 level (150.63 ± 73.89 pg/mL),followed by those with the GC genotype (108.63 ± 52.09 pg/mL,t =2.351,P =0.022) and GG (91.29 ± 54.31 pg/mL,t =3.091,P =0,003) homozygotes.We report the association of the-362G/C genetic polymorphism and increased plasma levels of MCP-1 in patients with spinal TB and nominate the-362C minor allele as a risk factor for spinal TB in the Chinese population.
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