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Despite the broad clinical applications of platinum-based anticancer drugs including cisplatin,their side-effects and resistance issues have encouraged researchers to look for novel metal-based anticancer complexes.Non-traditional platinum compounds have been extensively studied and they hold the promise to be further developed as the next-generation platinum drugs.On the other hand,using nanomaterials to deliver cisplatin specifically into cancer cells has proven to be promising to increase the anticancer efficacy of cisplatin and has been a hot topic in the recent years.In this presentation,I will summarize the recent progress in my laboratory in 1)the design,synthesis,and biological evaluation of dual-targeting non-traditional platinum anticancer agents and 2)investigation of the action mechanism of metal-based anticancer agents.Examples of platinum constructs that inhibit DNA damage repair and that can be activated in a controllable fashion will be given.