T淋巴细胞靶向EGFR治疗EGFR或EGFRvⅢ过表达的胶质母细胞瘤的基础与临床Ⅰ期研究

来源 :中华医学会2015全国神经肿瘤学术大会 | 被引量 : 0次 | 上传用户：oqo235

【摘要】

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【作者】

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邱永明翁维吉李宗海

【机构】

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上海交通大学医学院附属仁济医院神经外科上海市肿瘤研究所

【出处】

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中华医学会2015全国神经肿瘤学术大会

【发表日期】

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2015年5期

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胶质母细胞瘤(Glioblastoma,GBM)患者的中位生存期仅为14.6个月.GBM 治疗效果差,因此迫切需要寻找新的更有效的治疗方法.在GBM 中经常出现表皮生长因子受体(Epidermal growth factor receptor,EGFR)扩增和表皮生长因子受体Ⅲ型突变体(Epidermal growth factor receptor variant Ⅲ,EGFRvⅢ),所以EGFR 和EGFRvⅢ一直被视为GBM 潜在的治疗靶点.egfr287-302 是肿瘤特异性抗原表位,存在并暴露于过表达EGFR 和EGFRvⅢ的胶质瘤细胞中.

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T淋巴细胞靶向EGFR治疗EGFR或EGFRvⅢ过表达的胶质母细胞瘤的基础与临床Ⅰ期研究

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