论文部分内容阅读
BACKGROUND:Patients with chromosomal translocation are highly vulnerable to produce unbalanced gametes that result in recurrent miscarriages,affected offspring,or infertility.Preimplantation genetic diagnosis (PGD) and screening (PGS) are widely accepted for chromosomal abnormality identification to avoid transferring embryos with genetic defects.Massively parallel sequencing (MPS) is a rapidly developing approach for genome analysis with increasing application in clinical practice.The purpose of this study was to use MPS for identification of aneuploidies and unbalanced chromosomal rearrangements after blastocyst biopsy.