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  5. 镉对未成年雌性大鼠卵巢组织激素分泌的影响

镉对未成年雌性大鼠卵巢组织激素分泌的影响

来源 :中华医学会第七次全国生殖医学学术会议 | 被引量 : 0次 | 上传用户：shendongshendong
【摘 要】
：
目的 观察镉对未成年雌性大鼠卵巢组织雌、孕激素分泌的影响及其性腺毒性的作用机制.方法 健康清洁级未成年雌性SD大鼠38只,随机分为染镉高、中、低剂量组和对照组,前三组皮下注射氯化镉染毒,1次/d,每周5d,连续6周;对照组注射等量生理盐水.观察大鼠卵巢镉含量、动情周期,子宫、卵巢脏器系数及卵巢组织雌、孕激素水平.结果 与对照组比较,染镉组卵巢镉含量明显增加、动情周期明显延长,子宫、卵巢脏器系数及雌
【作 者】
：
张帆 张纯 郑洁 何联 杨萍 
【机 构】
：
华中科技大学同济医学院附属同济医院产科 湖北省妇幼保健院生殖中心
【出 处】
：
中华医学会第七次全国生殖医学学术会议
【发表日期】
：
2013年7期
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目的 观察镉对未成年雌性大鼠卵巢组织雌、孕激素分泌的影响及其性腺毒性的作用机制.方法 健康清洁级未成年雌性SD大鼠38只,随机分为染镉高、中、低剂量组和对照组,前三组皮下注射氯化镉染毒,1次/d,每周5d,连续6周;对照组注射等量生理盐水.观察大鼠卵巢镉含量、动情周期,子宫、卵巢脏器系数及卵巢组织雌、孕激素水平.结果 与对照组比较,染镉组卵巢镉含量明显增加、动情周期明显延长,子宫、卵巢脏器系数及雌孕激素水平明显降低.结论 镉可能通过降低卵巢组织雌、孕激素分泌影响未成年雌(女)性生殖内分泌系统,其具体机制有待深入研究.
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