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目的:探讨地黄提取物对阿霉素肾病大鼠的保护作用及其作用机制。方法:尾静脉注射阿霉素诱导建立阿霉素肾病大鼠模型,并随机分为对照组(C组)、阿霉素肾病模型组(M组)、地黄提取物治疗组(D组),治疗8周后观察各组尿蛋白、尿素氮、血肌酐及肾脏病理改变;比较各组肾组织纤维连接蛋白(FN)的表达水平。结果:D组各项指标与模型组相比均有统计学差异,形态学观察也显示其肾脏损害轻于模型组。与M组相比,C组及D组肾组织FN表达水平显著下降(P<0.05)。结论:地黄提取物对阿霉素肾病大鼠肾脏有一定的保护作用,其机制至少部分与下调肾组织FN的表达,抑制肾小球系膜过度增殖有关。
Objective: To investigate the protective effect of Rehmannia glutinosa extract on rats with adriamycin-induced nephropathy and its mechanism. METHODS: Adriamycin-induced nephropathy rat models were established by tail vein injection of adriamycin, and were randomly divided into control group (C group), adriamycin nephropathy model group (M group), and rehmannia root extract treatment group (D group). After 8 weeks of treatment, the urinary protein, urea nitrogen, serum creatinine, and pathological changes of the kidneys were observed. The expression of fibronectin (FN) in the renal tissues of each group was compared. RESULTS: There were statistical differences between the various indicators in the D group and the model group. Morphological observation also showed that the kidney damage was lighter than the model group. Compared with group M, the expression of FN in renal tissue of group C and group D was significantly decreased (P<0.05). Conclusion: Extract of Rehmannia glutinosa has protective effect on kidney of rats with adriamycin nephropathy, and its mechanism is at least partially related to down-regulation of FN expression in renal tissue and inhibition of excessive proliferation of glomerular mesangium.