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Various epidemiologic studies in recent years have indicated that light/moderate alcohol consumers have lower risks of nerve degenerative disease,suggesting that ethanol have neuroprotective effect.Ethanol is known to be involved in many signaling pathway,such as AMPK,protein kinase B/AKT and protein kinase C.Recently,some researches found that acute ethanol have neuroprotective effect,the mechanisms underlying it (acute ethanol-induced) are not completely understood.Integrating existing related research,it will be interesting to explore whether inhibit AMPK levels after acute ethanol administration is one of the mechanisms for neuroprotective effect.